Falciparum malaria--present day problems. An experience with 425 cases.
Identifieur interne : 003105 ( Main/Exploration ); précédent : 003104; suivant : 003106Falciparum malaria--present day problems. An experience with 425 cases.
Auteurs : S R Mehta ; G. Naidu ; V. Chandar ; I P Singh ; S. Johri ; R C AhujaSource :
- The Journal of the Association of Physicians of India [ 0004-5772 ] ; 1989.
Descripteurs français
- KwdFr :
- MESH :
- traitement médicamenteux : Paludisme.
- usage thérapeutique : Chloroquine, Oxytétracycline.
- Adolescent, Adulte, Adulte d'âge moyen, Animaux, Enfant, Enfant d'âge préscolaire, Femelle, Humains, Inde, Mâle, Nourrisson, Nouveau-né, Plasmodium falciparum, Sujet âgé.
- Wicri :
- geographic : Inde.
English descriptors
- KwdEn :
- MESH :
- chemical , therapeutic use : Chloroquine, Oxytetracycline.
- geographic : India.
- drug therapy : Malaria.
- Adolescent, Adult, Aged, Animals, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Middle Aged, Plasmodium falciparum.
Abstract
Clinical details and present day problems encountered in 425 cases of falciparum malaria (PF) are reported. 10.11% had taken chloroquine prior to reporting to us. Parasitic count done in 23.05% cases lacked correlation with severity of disease. Pattern of fever varied markedly but 5.4% were afebrile throughout and presented only with bodyache and malaise. Apyrexial spell was noted in 5.64%. 28.70% had typical facial looks of anaemia and sallow complexion. Cerebral symptoms were noted in 3.05%. Other symptoms were severe headache 33.4%, pain abdomen 3.29%, gastroenteritis 5.64%, jaundice 2.58% and bronchitis in 7.50%. We encountered subconjunctival haemorrhages with purpura and/or urticaria in four cases, symptoms suggestive of shock lung in 3, pulmonary oedema in 2, severe anaemia (HB less than 4 g%) in seven pregnant ladies, extrapyramidal symptoms in follow up period in 5 and congenital malaria in 2 cases. 83.25% were cured with chloroquine and oxytetracycline. 8.47% (who deteriorated despite the above treatment) were treated with quinine for 6 days. 5.17% (with severe disease) were also given quinine as first line drug. 2.82% (unresponsive to chloroquine and oxytetracycline but with mild disease) were treated with pyrimethamine-sulphamezathine combination for 5 days. One case who did not respond to quinine was treated with quinidine. Recrudescence was seen in 3.67% of patients treated with chloroquine and oxytetracycline. There was no case with renal failure, haemolysis due to G6PD deficiency and black water fever. There was only one death (0.23%) in our series. Self-medication, haphazard therapy and the slogan "Fever may be malaria-take chloroquine" can lead to problems in falciparum malaria.
PubMed: 2693436
Affiliations:
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An experience with 425 cases.</title><author><name sortKey="Mehta, S R" sort="Mehta, S R" uniqKey="Mehta S" first="S R" last="Mehta">S R Mehta</name></author><author><name sortKey="Naidu, G" sort="Naidu, G" uniqKey="Naidu G" first="G" last="Naidu">G. Naidu</name></author><author><name sortKey="Chandar, V" sort="Chandar, V" uniqKey="Chandar V" first="V" last="Chandar">V. Chandar</name></author><author><name sortKey="Singh, I P" sort="Singh, I P" uniqKey="Singh I" first="I P" last="Singh">I P Singh</name></author><author><name sortKey="Johri, S" sort="Johri, S" uniqKey="Johri S" first="S" last="Johri">S. Johri</name></author><author><name sortKey="Ahuja, R C" sort="Ahuja, R C" uniqKey="Ahuja R" first="R C" last="Ahuja">R C Ahuja</name></author></analytic><series><title level="j">The Journal of the Association of Physicians of India</title><idno type="ISSN">0004-5772</idno><imprint><date when="1989" type="published">1989</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Chloroquine (therapeutic use)</term><term>Female</term><term>Humans</term><term>India</term><term>Infant</term><term>Infant, Newborn</term><term>Malaria (drug therapy)</term><term>Male</term><term>Middle Aged</term><term>Oxytetracycline (therapeutic use)</term><term>Plasmodium falciparum</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Chloroquine (usage thérapeutique)</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Inde</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Oxytétracycline (usage thérapeutique)</term><term>Paludisme (traitement médicamenteux)</term><term>Plasmodium falciparum</term><term>Sujet âgé</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Chloroquine</term><term>Oxytetracycline</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>India</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Malaria</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Paludisme</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Chloroquine</term><term>Oxytétracycline</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Animals</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Middle Aged</term><term>Plasmodium falciparum</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Animaux</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Humains</term><term>Inde</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Plasmodium falciparum</term><term>Sujet âgé</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Inde</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical details and present day problems encountered in 425 cases of falciparum malaria (PF) are reported. 10.11% had taken chloroquine prior to reporting to us. Parasitic count done in 23.05% cases lacked correlation with severity of disease. Pattern of fever varied markedly but 5.4% were afebrile throughout and presented only with bodyache and malaise. Apyrexial spell was noted in 5.64%. 28.70% had typical facial looks of anaemia and sallow complexion. Cerebral symptoms were noted in 3.05%. Other symptoms were severe headache 33.4%, pain abdomen 3.29%, gastroenteritis 5.64%, jaundice 2.58% and bronchitis in 7.50%. We encountered subconjunctival haemorrhages with purpura and/or urticaria in four cases, symptoms suggestive of shock lung in 3, pulmonary oedema in 2, severe anaemia (HB less than 4 g%) in seven pregnant ladies, extrapyramidal symptoms in follow up period in 5 and congenital malaria in 2 cases. 83.25% were cured with chloroquine and oxytetracycline. 8.47% (who deteriorated despite the above treatment) were treated with quinine for 6 days. 5.17% (with severe disease) were also given quinine as first line drug. 2.82% (unresponsive to chloroquine and oxytetracycline but with mild disease) were treated with pyrimethamine-sulphamezathine combination for 5 days. One case who did not respond to quinine was treated with quinidine. Recrudescence was seen in 3.67% of patients treated with chloroquine and oxytetracycline. There was no case with renal failure, haemolysis due to G6PD deficiency and black water fever. There was only one death (0.23%) in our series. Self-medication, haphazard therapy and the slogan "Fever may be malaria-take chloroquine" can lead to problems in falciparum malaria.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Ahuja, R C" sort="Ahuja, R C" uniqKey="Ahuja R" first="R C" last="Ahuja">R C Ahuja</name><name sortKey="Chandar, V" sort="Chandar, V" uniqKey="Chandar V" first="V" last="Chandar">V. Chandar</name><name sortKey="Johri, S" sort="Johri, S" uniqKey="Johri S" first="S" last="Johri">S. Johri</name><name sortKey="Mehta, S R" sort="Mehta, S R" uniqKey="Mehta S" first="S R" last="Mehta">S R Mehta</name><name sortKey="Naidu, G" sort="Naidu, G" uniqKey="Naidu G" first="G" last="Naidu">G. Naidu</name><name sortKey="Singh, I P" sort="Singh, I P" uniqKey="Singh I" first="I P" last="Singh">I P Singh</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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